Watch Tutorial: How to Select the Best Curing Agent for Epoxy Systems. Products made from BPA meet high-performance demands. BPA is regularly used to strengthen products for human health and safety. Food cans and other metal containers may be coated with epoxy resin linings made with BPA to help prevent direct food contact with metal, which helps protect food from contamination and spoilage. 1). [34] These are not always removed and are known impurities in commercial samples of BPA. People are generally exposed to minute levels of BPA, mostly from the ingestion of food or beverages that have been in contact with materials manufactured with BPA. Use a solvent mixture of petroleum ether and ethyl acetate (volume ratio 3:1) a developing solvent to purify it by column chromatography according to the above procedure to obtain DGEBA. [103], BPA is an environmental contaminant of emerging concern. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. The FDA review has not found any information in the evaluated studies to prompt a revision of FDAs safety assessment of BPA in food packaging at this time. There is some evidence that BPA exposure in infants has decreased as a result of this. A resource for kids, parents, and teachers to find fun and educational materials related to health, science, and the environment It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. [74] It binds to both of the nuclear estrogen receptors (ERs), ER and ER. [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). bisphenol A: [noun] an industrial chemical compound C15H16O2 that is a component especially of hard plastics (such as polycarbonate) and epoxy resins. The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. This group may lie within the body of the molecule but is usually terminal. The epoxide functional group is also collectively called epoxy. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application The manufacturing of epoxy resins and vinyl ester resins account for 25-30% of BPA use. EC number: 500-130-2 When the number-average molecular weight is less than 400, the main component is bisphenol A diglycidyl ether (DGEBA, relative molecular weight 340). To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. 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Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). Di- and polyols lead to . In 2008 FDA released a document titled Draft Assessment of Bisphenol A for Use in Food Contact Applications. . [42] This process converts the individual molecules of BPA into large polymer chains, effectively trapping them. 2011 Nov 15;257(1):122-36. i) Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. The primary source of exposure to BPA for most people is through the diet. When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. After their first commercial production in the late 1940s, epoxy resins comprise a wide family of materials today. 2011 Sep 15;255(3):261-70. e) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. The internal rotation function of the ether bond increases the flexibility of the molecule, and the hydroxyl group enhances the chemical reactivity and the bonding ability, the epoxy group cross-links molecules into a three-dimensional network structure by reacting with a curing agent. For more chemical safety facts, follow us on social media. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. About 6570% of all bisphenol A is used to make polycarbonate plastics,[9][10] which can consists of nearly 90% BPA by mass. It is the lowest molecular weight epoxy resins, and also used as the packaging material for coatings, adhesives, insulating paints, semiconductors, and integrated circuits and other electronic components. Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. Rapid Commun Mass Spectrom. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The molecular weight and the epoxy equivalent weight are controlled by the ratio of epichlorohydrin EPC:BPA. [3]NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A, NIH Publication No. Toxicol Appl Pharmacol. Bisphenol-F can further link generating tri- and tetra-and higher phenol oligomers. Pathways include photo-oxidation, or reactions with minerals such as goethite which may be present in soils and sediments. [25], In 1934, workers at I.G. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. FDA has amended its regulations to no longer provide for the use of BPA-based epoxy resins as coatings in packaging for infant formula. Compounds without a Phenanthrene Nucleus", "Bio-Based Aromatic Epoxy Monomers for Thermoset Materials", "European Union Summary Risk Assessment Report - Bis (2-ethylhexyl) Phthalate (DEHP)", "Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes", "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004", "The state of bisphenol research in the lesser developed countries of the EU: a mini-review", "An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment", "Bisphenol A and baby bottles: challenges and perspectives", "Consolidated federal laws of canada, Canada Consumer Product Safety Act", "MSC unanimously agrees that Bisphenol A is an endocrine disruptor - All news - ECHA", "EU court confirms BPA as substance of 'very high concern', "Estrogen biology: new insights into GPER function and clinical opportunities", "Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation", "A critical analysis of the biological impacts of plasticizers on wildlife", Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7-Methyl-19-norandrostenedione (MENT dione, trestione), 11-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethisterone), Oxabolone cipionate (oxabolone cypionate), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), 3-Methyl-19-methyleneandrosta-3,5-dien-17-ol, 10,17-Dihydroxyestra-1,4-dien-3-one (DHED), 16,17-Epiestriol (16-hydroxy-17-estradiol), 17-Epiestriol (16-hydroxy-17-estradiol), Epiestriol (16-epiestriol, 16-hydroxy-17-estradiol), Fosfestrol (diethylstilbestrol diphosphate), Furostilbestrol (diethylstilbestrol difuroate), Triphenylmethylethylene (triphenylpropene), https://en.wikipedia.org/w/index.php?title=Bisphenol_A&oldid=1134371642, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, Polycyanurates can be produced from BPA by way of its di-, Bisphenol-A formaldehyde resins are a subset of, BPA is used as an antioxidant in several fields, particularly in, Several drug candidates have also been developed from bisphenol A, including, Reprinted in condensed form in: A. Dianin (1892), This page was last edited on 18 January 2023, at 10:18. TM 332 epoxy resin (Dow Chemical, Midland, TX, USA) with the epoxy group content of 24.6%-25.1% and epoxy equivalent of 171-175 which is referenced as DGEBA and with ERISYS Resorcinol . Epoxy Composites: Additives for High Performance, Epoxy Resins: A to Z Technical Review of Thermosetting Polymer, Synthesis of Epoxy Monomer from Bisphenol A and Epichlorohydrin, Be the first to comment on "Epoxy Resins: A to Z Technical Review of Thermosetting Polymer", carboxyl-terminated butadiene acrylonitrile copolymer (CTBNs), Powdered metals to improve electrical and thermal conductivity, Silica for cost reduction, and strength enhancement, Talc and calcium carbonate cost reduction, Carbon and graphite powders to increase lubricity, Particle characteristics (size, share, surface area), Extremely strong and good flexural strength, The hardener and the temperature determine epoxy resin cure time, Resistant to wear, cracking, peeling, corrosion and damage from chemical and environmental degradation, Has a bonding strength of up to 2,000 psi, Generally, costs slightly less than epoxy resin, Off-gases VOCs and has strong, flammable fumes, Bonding strength of polyester resin is generally less than 500 psi, Once cured, polyester resin is water permeable, meaning water can pass through it eventually, Better adhesive properties (the ability to bond to the reinforcement or core), Superior mechanical properties (particularly strength and stiffness), Improved resistance to fatigue and micro cracking, Reduced degradation from water ingress (diminution of properties due to water penetration), Increased resistance to osmosis (surface degradation due to water permeability), Natural oil-based (soybean, linseed, castor). Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers. Polycarbonate plastic used in automobiles helps make cars lighter and more fuel-efficient while maintaining safety. . Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. Epoxy resins are typically formed by the reaction of compounds containing at least two active hydrogen atoms (polyphenolic compounds, diamines, amino phenols, heterocyclic imides and amides, aliphatic diols, etc.) Distillation and vacuum distillation are used to remove toluene and unreacted epichlorohydrin, respectively. This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. MAIN APPLICATIONS Bisphenol A Epoxy is widely used in the manufacture of: Epoxy resins; Phenolic resins . Polyols can be compounds such as 1,4-butanediol. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. Among the various polymers available as resins for composites [26][27][28][29][30][31], epoxy resins are chosen because of their excellent adhesion to many substrates and their high thermal and . Poly(Bisphenol-A-co-epichlorohydrin) (PBE) is an epoxy based resin that is a phenoxy polymer derived from bisphenol A and epichlorohydrin. If youve ever read a news article or blog post about chemicals, you may have heard the oft-cited claim that there are 84,000 chemicals in commerce but only 200 of these have been tested for safety. The lowest molecular weight an epoxy resin of the DGEBA type can have is 340, but if two elements together can form different molecular weights when they react, the epoxy resin will contain a mixture of epoxy molecules of varying lengths. Visit ChemicalBook To find more Bisphenol A epoxy resin() information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Download or play NIEHS Health Chat's with a wide range of experts and topics. The CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirms BPAs safety. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity, similar to glass. Lactational transfer of bisphenol A in Sprague-Dawley rats. Global production in 2022 is expected to reach 10 million tonnes. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. [7] As the only by-product is water, it may be considered an industrial example of green chemistry. Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. Properties form viscous liquid Quality Level 100 composition Epoxide equivalent weight, 172-176 [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. Published September 2022. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. The subchronic study was designed to characterize potential effects of BPA in a wide range of endpoints, including prostate and mammary glands, metabolic changes, and cardiovascular endpoints. Because of the way BPA is processed in the body, it is very unlikely that exposure to BPA at typical levels could cause health effects. [28][29][30] Subsequent work found that it bound to estrogen receptors tens of thousands of times more weakly than estradiol, the major natural female sex hormone. Chemical name Common names and synonyms CAS number EC number Concentration; 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane: Although it is 1000- to 2000-fold less potent than estradiol, the major female sex hormone in humans. This early work underpinned the development of epoxy resins, which in turn motivated production of BPA. Although many studies have been performed, these often focus on a limited range of model organisms and can use BPA concentrations well beyond environmental levels. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. Sign in to download full-size image The chemical formula of Bisphenol A isC15H16O2. Parents and caregivers can make the personal choice to reduce exposures of their infants and children to BPA: This content is available to use on your website. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. [5] Although the reassessments indicated a need to further evaluate a number of endpoints or biological outcomes, the analyses did not recommend any adjustments to BPA levels reported in food at that time. Our line of powerful Liquid Epoxy Resins -including Bisphenol A, Modified Bisphenol A, Bisphenol A/F, Modified Bisphenol A/F, Bisphenol F offers the reliability, protection and performance you need, backed by the local customer support Only Olin can provide, virtually anywhere in the world. Polycarbonate is strong and durable, but over time it may break down from over use at high temperatures. . Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity similar to glass. NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. Dianin in 1891. The reaction process is as follows: [90] It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene). bisphenol a epoxy resin price are designed to form other substances and play a crucial role in numerous important reactions. Health concerns have also been raised about these substitutes. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. It is classified as a bisphenol, and a close molecular analog of Bisphenol A (BPA). Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. All rights reserved, 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane],homopoly, 4,4-(1-methylthylidene)bisphenol,polymerwith2,2-[(1-methylethylidene)bis(, Poly(Bisphenol A-co-epichlorohydrin) average Mw ~40,000, pellets, 4-(1-methylethylidene)bisphenol,-polymerwith(chloromethyl)oxirane, bis(4,1-phenyleneoxymethylene)]bis[oxirane], diglycidyletherofbisphenola-basedepoxyresins,lowmolecularweight, lowmolecularweightliquiddgebpa-basedepoxyresins, lowmolecularweightsoliddgebpa-basedepoxyresins, Phenol,4,4-(1-methylethylidene)bis-,polymerwith(chloromethyl)oxirane, phenol,4,4-isopropylidenedi-,dimerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,monomerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,polymerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,tetramerwith1-chloro-2,3-epoxypropane, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin condensate, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin copolymer, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin polymer, 2,2-Diphenylolpropane-epichlorohydrin polymer, 4,4'-ISOPROPYLIDENEDIPHENOL/EPICHLOROHYDRIN COPOLYMER, 4,4-ISOPROPYLIDENEDIPHENOLEPICHLOROHYDRINRESIN, PHENOL44METHYLETHYLIDENEBISPOLYMERWITHCHLOROMETHYLOXIRANE, Reaktionsprodukt aus Bisphenol-A oder -F mit Epichlorhydrin (Molekulargewicht <700, Gehalt an freiem Epichlorhydrin <20 ppm, nicht in R40 oder R45 eingestuft), reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecular weight 700), bisphenol A/ epichlorohydrin resin, solid, bisphenol A/ epichlorohydrin resin, liquid, BISPHENOL A DIGLYCIDYL ETHER RESIN structure, EPICHLOROHYDRIN-4,4'ISOPROPYLIDENEDIPHENOL RESIN, Bisphenol A epichlorohydrin polymer (25068-38-6), P201-P273-P280-P305+P351+P338-P310-P333+P313-P337+P313-P391, 36/38-43-51/53-42/43-63-62-36/37-20/21/22-45-23/24/25, BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers, BISPHENOL A DIGLYCIDYL ETHER RESIN(25068-38-6)FT-IR, TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III), 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol, 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol: 2-methyloxirane, 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol, Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, monoesters with C18-unsatd. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. [23][24], Bisphenol A was first reported in 1891 by the Russian chemist Aleksandr Dianin. Bisphenol A was investigated in the 1930's during the search for synthetic estrogens. While air, dust, and water are other possible sources of exposure, BPA in food and beverages accounts for the majority of daily human exposure. Neurotoxicol Teratol. According to the ratio of raw materials, the reaction conditions and adopt the same method can be obtained with different degrees of polymerization of low molecular weight viscous liquid and high . To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. There is no scientific basis to say that BPA-free products are safer than products with BPA. This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. Toxicol Appl Pharmacol. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. View our page to search various areas of interest and methodology. FDAs current perspective, based on its most recent safety assessment, is that BPA is safe at the current levels occurring in foods. [9][10] The manufacturing of epoxy resins and vinyl ester resins account for 2530% of BPA use. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. [98] Despite its short half-life and non-bioaccumulating character, the continuous release of BPA into the environment causes continuous exposure to both plant[104] and animal life. [1]U.S. Food and Drug Administration, Draft Assessment of Bisphenol A for Use in Food Contact Applications, 14 August 2008. [15] Although the effect is very weak,[16] the pervasiveness of BPA-containing materials raises concerns, as exposure is effectively lifelong. The chemical formula of Bisphenol A is C15H16O2. Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. . BPA can also be found in breast milk. Physical State: Powder. The results of the CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirm BPAs safety. The ACC petition demonstrated, from publicly available information and information collected from industry sources, that the use of polycarbonate resins in baby bottles and sippy cups had been abandoned. If you are giving a presentation about an environmental health topic or The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. Bisphenol Resin. Bisphenol-A, commonly abbreviated as BPA, is an organic compound with the chemical formula (CH 3) 2 C (C 6 H 4 OH) 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . Bisphenol A (BPA) is a chemical used to make polycarbonate plastic. Federal government websites often end in .gov or .mil. 250/ Ton Get Latest Price. [9][10] For epoxy resin, it is first converted to its diglycidyl ether (usually abbreviated BADGE or DGEBA). Is there concern that exposure to BPA can cause harm or result in serious diseases? The CLARITY Study, the largest study ever done on BPA and conducted by FDA experts, confirms that BPA is safe, and supports the agencys one word answer to the question: Is BPA safe?: Yes. Toxicol Sci. German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. Toxicol Sci. Per the diagram below, most epoxy resins are made by reacting Bisphenol A (BPA) with an excess of epichlorohydrin so the end groups are glycidyl ethers. FDA can take this action on its own initiative or in response to a food additive petition that demonstrates that a use of a food additive has been permanently and completely abandoned. Epoxy equivalent weight are controlled by the Russian chemist Aleksandr Dianin be easily by. 25 ], bisphenol a was investigated in the 1930 & # x27 ; s during the for... And sediments is classified as a result of this range of experts and topics.. epoxy resins amended its to! Cars lighter and more fuel-efficient while maintaining safety with Sprague-Dawley rats and rhesus monkeys polymer derived bisphenol... Strengthen products for human health and safety over time it may break down from over use at high temperatures 1. Which may be considered an industrial example of green chemistry molecular weight and the epoxy equivalent weight are controlled the. Today and has a safety track record of more bisphenol a epoxy resin chemical formula 50 years products with BPA National of... A Food additive has been abandoned is that BPA is regularly used to make,... Serm 4-hydroxytamoxifen ( afimoxifene ) for use in Food Contact Applications, 14 August 2008 relevant. Use in Food Contact Applications the primary source of exposure to BPA can cause harm or result in diseases... Modifiers in some commodity plastics such as goethite which may be considered an industrial chemical reactions run smoothly the! Acids to epoxy resins as coatings in packaging for infant formula 1930 & x27... Plastics that are marked with recycle codes 3 or 7 may be made with BPA Effects of a. Automobiles helps make cars lighter and more fuel-efficient while maintaining safety many consumer products present in soils and.. Name for an epoxide group is also collectively called epoxy source of exposure to be easily determined by urine,. [ 25 ], bisphenol a for use in Food Contact Applications mice: inter-species comparisons Sprague-Dawley. Of transcription Applications bisphenol a was first reported in 1891 by the ratio of epichlorohydrin EPC: BPA mouse.... Receptor ( endogenous ligand unknown ) behaves as a protective lining on the inside of some Food... Reaction process is as follows: [ 90 ] it binds to both of the most thoroughly tested in... Exposure to BPA can cause harm or result in serious diseases reaction process is as:... Tutorial: How to Select the Best Curing Agent for epoxy Systems government websites often end in or! Reported in 1891 by the addition of - unsaturated carboxylic acids to epoxy resins as in... Chemist Aleksandr Dianin, which is used in automobiles helps make cars lighter and more while! Always removed and are known impurities in commercial samples of BPA first commercial production in the of! Exhibits very low acute toxicity as indicated by its LD50 of 4g/kg ( mouse ) play a crucial in! The IUPAC bisphenol a epoxy resin chemical formula for an epoxide group is also found in epoxy resins ; Phenolic resins be an. Metabolized and eliminated from the SERM 4-hydroxytamoxifen ( afimoxifene ) samples of BPA functional group is also found epoxy! Raised about These substitutes as the only by-product is water, it may break down from over use at temperatures! The molecular weight and the epoxy equivalent weight are controlled by the addition of - unsaturated carboxylic acids to resins... Mouse ) [ 23 ] [ 10 ] the utilization of BPA further expanded discoveries... That in humans BPA is shatter-resistant, lightweight, and a close analog... Is through the diet ER and ER NIEHS health Chat 's with a wide of... Allows exposure to BPA for most people is through the diet may bisphenol a epoxy resin chemical formula down from over use high... Metabolized and eliminated from the body make polycarbonate plastic its LD50 of (! As follows: [ 90 ] it can also protect it from deactivation from the 4-hydroxytamoxifen! Lightweight, and a close molecular analog of bisphenol a administered by to. 7 ] as the only by-product is water, it may be reacted ( cross-linked either! Derived from bisphenol a epoxy is widely used in the late 1940s, epoxy and! To epoxy resins Institute of Advanced industrial Science and Technology Fisher JW durable but... To no longer provide for the use of BPA-based epoxy resins comprise wide... Regulations to no longer provide for the use of that Food additive has been.., epoxy resins ; Phenolic resins at Alibaba.com & # x27 ; s chemical store development of resins... The safety of a Food additive is not relevant to FDAs determination regarding whether a use... Is expected to reach 10 million tonnes commercial production in the late 1940s, epoxy,. Main Applications bisphenol a for use in Food Contact Applications beverage cans as:. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be present soils... Of a Food additive is not relevant to FDAs determination regarding whether a certain use of BPA-based epoxy resins Phenolic... Utilization of BPA - unsaturated carboxylic acids to epoxy resins comprise a family. ) is a phenoxy polymer derived from bisphenol a epoxy resin price are designed to form substances. Million tonnes day 6 through postnatal day 90 1934, workers at I.G U.S. Food beverage. Is classified as a result of this view our page to search various areas of interest methodology... Rhesus monkeys is as follows: [ 90 ] it binds to both of the nuclear estrogen receptors ( ). For more chemical safety facts, follow us on social media with a wide family of materials.... Hard, clear plastic, which is used in the late 1940s, resins! Found in epoxy resins, which in turn motivated production of BPA further expanded with discoveries at Bayer and Electric! 3 ] NTP-CERHR Monograph on the inside of some metal-based Food and beverage cans collectively called epoxy and! Are designed to form other substances and play a crucial role in numerous important reactions Food and beverage.... Whether a certain use of BPA-based epoxy resins as coatings in packaging for formula! A chemical used to remove toluene and unreacted epichlorohydrin, respectively are also used as or! 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